JOHANNESBURG, SOUTH AFRICA DECEMBER 02: (SOUTH AFRICA OUT): American talkshow host Oprah Winfrey speaks during a Dreams programme event at the Premier Hotel in OR Tambo Airport on December 02, 2016 in Johannesburg, South Africa. Winfrey surprised the youth ambassadors enrolled in the US embassy HIV awareness programme aimed at reducing the HIV infection in adolescent girls when she shared her inspirational story of overcoming poverty and sexual assault. (Photo by Moeletsi Mabe/Sunday Times/Gallo Images/Getty Images)
Sunday Times—Getty Images
By Aurelie Corinthios / People
April 14, 2017

It’s been six years since ‘s beloved talk show went off the air — and now, she’s reflecting on what it taught her.

In an interview with PEOPLE and Entertainment Weeklys Editorial Director for the latest edition of , excerpted in this week’s issue of PEOPLE, the TV queen — and star of HBO’s upcoming — opens up about life after .

During the interview at , Winfrey, 63, admits that it wasn’t easy to adjust to life without the show, which ran for 25 seasons from 1986 to 2011 and remains one of the highest-rated talk shows in American television history.

“For about two years, I was off balance,” says Winfrey. “I was so accustomed to having an itinerary done for me and that itinerary just being jammed from the time I got up in the morning. I wouldn’t even look at it until was I done with the day. I’d just say, ‘Where am I next? What do we do now?’ ”

  • Watch the full episode of , streaming now on People/Entertainment Weekly Network (PEN). Go to , or download the app for Apple TV, Roku, Amazon Fire TV, Xumo, Chromecast, Xfinity, iOS and Android devices. And for more on Oprah and Henrietta Lacks, pick up this week’s issue of PEOPLE, on newsstands Friday.

Despite the challenges of adjusting to her new life, Winfrey says she was “never depressed” after the show ended.

“I was just like, ‘Oh, okay. It’s 7:30, and I woke up when I heard the birds,’ ” she says. “I had to figure out how to set a schedule based on what I want to do. I don’t have to be in the office at any certain time. I don’t have a 9:00 show and a 1:00 show and then a 3:00 meeting afterwards.”

“How do I now kind of create a life based on what I want?” she continues. “I didn’t know what I wanted, so it took me a while to figure that out.”

The Immortal Life of Henrietta Lacks premieres April 22 at 8 p.m. ET on HBO.

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